Beilstein J. Org. Chem.2020,16, 2739–2748, doi:10.3762/bjoc.16.224
formation of a new derivative of caffeine.
Keywords: adenine; caffeine; cyclicdimerofhexafluorothioacetone; hexafluoroisopropyl group; purine; 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane; theophylline; Introduction
Despite significant progress in the last 20–30 years, the selective introduction of
PDF
Graphical Abstract
Scheme 1:
Reaction of purine (2) with tetrakis(trifluoromethyl)-1,3-dithietane (1).